I’d say at the slightest hint of a tug/pull/irritation/whatever. But in fact, I load a fresh blade before that. I shave 5 days/week, I use a blade 2 weeks then change it before I know it’s going to give me problems. I’ve been using Personna med preps, that equates to a whopping 2.5 cents per shave, why even bother to stretch it? I’m certain I use far more than 2.5 cents worth of cream each shave and I don’t fret when I see the bulk of it going down the drain upon rinsing brush and bowl.