I'd love to "like" turtle's post with the Winchester Model 1910 and ammunition. I'd love to have a Winchester Model 1910 .401.
My victory model shoots VERY well.
Break apart (fragmentation) and shot rounds should be your first choice for home defense. FMJ is military and not right for home defense (IMHO anyway).
https://en.wikipedia.org/wiki/Glaser_Safety_Slug
If you live in a solid pour cement block house (like we do) it is not critical unless you are unlucky and a round goes through a window.
I normally stash a 12 gauge with 00 buck by the bed, after seeing many positive results for HD use I may switch to bird shot. At HD distances it still makes a heck of a hole because of the tight pattern but you don't have as much of the over penetration to contend with.