So I finally decided to get a Filson large briefcase. This is all your fault!! I cannot recommend the bag more. It is incredible! It is going to replace my Tumi. I'll see how my colleagues react when I bring it to work tomorrow for the first time. The dress code is somewhat conservative.
I had a ballistic nylon phase but I really prefer natural materials: the way they feel and how they wear.
My only complaint is that the inside compartments are oddly shaped. Not a big deal, I don't really use them.
Thanks to everyone on the forum who recommended the bag.