Linalool is fairly commonly implicated in contact dermatitis seen in dermatology practices. Around 5-ish percent of the general population by report can exhibit hypersensitivity - about the same, interestingly enough, as reactions to tea tree oil or other EOs. For reference:
Allergy to oxidized limonene and linalool is frequent in the U.K - PubMed
This large, multicentre U.K. audit shows a significant rate of allergy to the hydroperoxides of limonene and linalool plus a high rate of irritant reactions. Testing to the oxidized forms alone captures the majority (97·0%; 411 of 422) of positive reactions; testing to nonoxidized terpenes...pubmed.ncbi.nlm.nih.gov
Oxidized limonene and oxidized linalool - concomitant contact allergy to common fragrance terpenes - PubMed
The majority of the patients (75%) reacted to only one of the oxidation mixtures, thus supporting the specificity of the reactions. The concomitant reactions to the two fragrance allergens suggest multiple sensitizations, which most likely reflect the exposure to the different fragrance...pubmed.ncbi.nlm.nih.gov
Allergic Contact Dermatitis to Fragrances - PubMed
Allergic contact dermatitis to fragrance is common. The prevalence of fragrance allergy in the general population is between 0.7% and 2.6%. In patch-test populations, the positive reaction rate to fragrances ranges from 5% to 11%. The most common fragrance screeners in most baseline series...pubmed.ncbi.nlm.nih.gov
Contact allergy to essential oils cannot always be predicted from allergy to fragrance markers in the baseline series - PubMed
A small number of patients who are allergic to essential oils could be missed if these are not specifically tested. Labelling by INCI names means that exposure may not be obvious. Careful inspection of so-called 'natural' products and targeted testing is recommended.pubmed.ncbi.nlm.nih.gov
Fragrance contact allergy: a 4-year retrospective study - PubMed
Classic markers detect the majority of cases of fragrance contact allergy. We recommend incorporating FM II in the Spanish baseline series, as in the European baseline series, and using a specific fragrance series to study patients allergic to a fragrance marker.pubmed.ncbi.nlm.nih.gov
You learn something every day, I never knew there was such a thing as linalool.
Linalool, (+/-)-
Linalool, (+/-)- | C10H18O | CID 6549 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
pubchem.ncbi.nlm.nih.gov
Last edited: